A quantitative and sound measurement serving this particular purpose remains elusive due to multiple challenges associated with biomechanical modeling of the brain. Coupling with physiological parameters that are readily available using MRI, eg, tissue perfusion, a non-invasive, quantitative and regional estimation of intracranial stress distribution could offer a better understanding of brain tissue’s reaction under mass effect. Estimation of intracranial stress distribution caused by mass effect is critical to the management of hemorrhagic stroke or brain tumor patients, who may suffer severe secondary brain injury from brain tissue compression.